Longitudinal observations of sympathetic neural activity and hemodynamics during 6 months recovery from SARS‐CoV‐2 infection

Autor: Nina L. Stute, Rachel E. Szeghy, Jonathon L. Stickford, Valesha P. Province, Marc A. Augenreich, Stephen M. Ratchford, Abigail S. L. Stickford
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Physiological Reports, Vol 10, Iss 18, Pp n/a-n/a (2022)
Druh dokumentu: article
ISSN: 2051-817X
DOI: 10.14814/phy2.15423
Popis: Abstract Cross‐sectional data indicate that acute SARS‐CoV‐2 infection increases resting muscle sympathetic nerve activity (MSNA) and alters hemodynamic responses to orthostasis in young adults. However, the longitudinal impact of contracting SARS‐CoV‐2 on autonomic function remains unclear. The aim of this study was to longitudinally track MSNA, sympathetic transduction to blood pressure (BP), and hemodynamics over 6 months following SARS‐CoV‐2 infection. Young adults positive with SARS‐CoV‐2 reported to the laboratory three times over 6 months (V1:41 ± 17, V2:108 ± 21, V3:173 ± 16 days post‐infection). MSNA, systolic (SBP) and diastolic (DBP) blood pressure, and heart rate (HR) were measured at rest, during a cold pressor test (CPT), and at 30° head‐up tilt (HUT). Basal SBP (p = 0.019) and DBP (p
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