The effect of aerobic exercise on lon protease 1 and heat shock protein 70 levels in mice with type 2 diabetes
| Autor: | Mehrzad Shabani, Vahid Valipour-Dehnou, Mohammad Reza Tabandeh, Mahdieh Molanouri-Shamsi |
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| Jazyk: | perština |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Fiyz̤, Vol 26, Iss 4, Pp 388-397 (2022) |
| Druh dokumentu: | article |
| ISSN: | 1029-7855 2008-9821 |
| Popis: | Background: Heat shock protein 70 (HSP70) and lon protease 1 (LONP1) are thought to be indicators of mitochondrial stress, which is essential for cell survival. This study aimed to investigate the effect of endurance exercise on changes in HSP70 and LONP1 in diabetic mice. Materials and Methods: This study was experimental and thirty adult mice were randomly and equally divided into three groups: control (C; n=10), diabetic (D; n=10) and diabetic-exercise (DE; n=10). Diabetes was induced by intraperitoneal injection of streptozotocin. Aerobic endurance training was performed for eight weeks. 48 hours after the last training session, glucose, insulin, HSP70 levels, LONP1 levels and insulin resistance index were measured. Results: Insulin, blood glucose levels and insulin resistance in group DE decreased significantly compared to group D (P |
| Databáze: | Directory of Open Access Journals |
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