| Autor: |
Vitaliy A. Matveev, Erik Z. Mihelic, Erika Benko, Patrick Budylowski, Sebastian Grocott, Terry Lee, Chapin S. Korosec, Karen Colwill, Henry Stephenson, Ryan Law, Lesley A. Ward, Salma Sheikh-Mohamed, Geneviève Mailhot, Melanie Delgado-Brand, Adrian Pasculescu, Jenny H. Wang, Freda Qi, Tulunay Tursun, Lela Kardava, Serena Chau, Philip Samaan, Annam Imran, Dennis C. Copertino, Jr., Gary Chao, Yoojin Choi, Robert J. Reinhard, Rupert Kaul, Jane M. Heffernan, R. Brad Jones, Tae-Wook Chun, Susan Moir, Joel Singer, Jennifer Gommerman, Anne-Claude Gingras, Colin Kovacs, Mario Ostrowski |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
iScience, Vol 26, Iss 10, Pp 107915- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2023.107915 |
| Popis: |
Summary: Older individuals and people with HIV (PWH) were prioritized for COVID-19 vaccination, yet comprehensive studies of the immunogenicity of these vaccines and their effects on HIV reservoirs are not available. Our study on 68 PWH and 23 HIV-negative participants aged 55 and older post-three vaccine doses showed equally strong anti-spike IgG responses in serum and saliva through week 48 from baseline, while PWH salivary IgA responses were low. PWH had diminished live-virus neutralization responses after two vaccine doses, which were ‘rescued’ post-booster. Spike-specific T cell immunity was enhanced in PWH with normal CD4+ T cell count, suggesting Th1 imprinting. The frequency of detectable HIV viremia increased post-vaccination, but vaccines did not affect the size of the HIV reservoir in most PWH, except those with low-level viremia. Thus, older PWH require three doses of COVID-19 vaccine for maximum protection, while individuals with unsuppressed viremia should be monitored for adverse reactions from HIV reservoirs. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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