Characteristics of Café-au-lait Macules and their Association with the Neurofibromatosis type I Genotype in a Cohort of Greek Children

Autor:	Lamprini Nasi, Alexios Alexopoulos, Eleftheria Kokkinou, Kleoniki Roka, Maria Tzetis, Maria Tsipi, Talia Kakourou, Christina Kanaka-Gantenbein, George Chrousos, Antonis Kattamis, Roser Pons
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	neurofibromatosis café-au-lait macules pigment intensity melanin genotype Dermatology RL1-803
Zdroj:	Acta Dermato-Venereologica, Vol 103 (2023)
Druh dokumentu:	article
ISSN:	0001-5555 1651-2057
DOI:	10.2340/actadv.v103.5758
Popis:	Cafe-au-lait macules are the most distinctive clinical finding in neurofibromatosis type I. The aim of this prospective study of Greek children diagnosed with neurofibromatosis type I was to describe the dermatological phenotype and to analyse the characteristics of cafe-au-lait macules and their association with genotype. Pigment intensity and melatonin content of cafe-au-lait macules were measured with a narrowband spectrophotometer. A total of 63 children aged 6 months to 16 years old were studied. Mean melanin content varied, both among patients, and within each patient (p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/09f52d42d3be471aba1fba0d8682fec1 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF