Combinational Effects of Prebiotics and Soybean against Azoxymethane-Induced Colon Cancer In Vivo

Autor: V. P. Gourineni, M. Verghese, J. Boateng, L. Shackelford, N. K. Bhat, L. T. Walker
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Journal of Nutrition and Metabolism, Vol 2011 (2011)
Druh dokumentu: article
ISSN: 2090-0724
2090-0732
DOI: 10.1155/2011/868197
Popis: Prebiotic fructans are nondigestible carbohydrates with numerous health benefits. Soybean is a rich source of phytonutrients such as isoflavones. The objective of this study was to evaluate the chemopreventive effects of prebiotics (Synergy1) and soybean meal (SM) at 5% and 10% levels alone and in combination on azoxymethane- (AOM-) induced colon carcinogenesis. After one wk of acclimatization, Fisher 344 male rats (N=90) were randomly assigned to 9 groups (n=10). Control rats (C) were fed AIN-93G/M. Two s/c injections of AOM were administered to rats at 7 and 8 wk of age at 16 mg/kg body weight. Rats were killed by CO2 asphyxiation at 45 wk. Tumor incidence (%) in treatment groups ranged from 40 to 75 compared to 100 in C. Results indicate that feeding prebiotics and soybean in combination significantly reduced incidence of AOM-induced colon tumors with implications for food industry in the food-product development.
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