| Popis: |
Objective: The aim of this work was to explore the hypoglycemic effect of Enteromorpha prolifera polyphenols (EPP) on type 2 diabetic mice, and to provide theoretical basis for the development of EPP products. Methods: EPP crude was extracted from Enteromorpha prolifera by ethanol solution extraction, and purified by silica gel column chromatography. The model of type 2 diabetes in mice was established by alloxan. The experimental mice were divided into blank control group, model control group, EPP low dose group (EPP-L), EPP midium dose group (EPP-M), EPP high dose group (EPP-H), and positive control group. The basic indicators of mice, as well as lipid metabolism and serum antioxidant indicators, were measured by continuous gastric perfusion for 4 weeks. Results: At the 4th week of the experiment, the averaged weight of mice in EPP-H group reached 32.16±1.97 g, which was not significantly different from that of the positive control group (P>0.05). The fasting blood glucose concentration of EPP-H group was 11.78±1.62 mmol/L, and there was no significant difference between EPP-H group and the positive control group (P>0.05). EPP-H clearly had significantly improved both the glucose tolerance (P |
