Clinical Characteristics and Optimal Therapy of Acute Myeloid Leukemia with Myelodysplasia-Related Changes: A Retrospective Analysis of a Cohort of Chinese Patients

Autor: Lei Wang, Xiaoxia Chu, Jingyao Wang, Licai An, Yinghui Liu, Li Li, Junqing Xu
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Turkish Journal of Hematology, Vol 38, Iss 3, Pp 188-194 (2021)
Druh dokumentu: article
ISSN: 1308-5263
DOI: 10.4274/tjh.galenos.2021.2021.0009
Popis: Objective: This study aimed to investigate the clinical characteristics of acute myeloid leukemia with myelodysplasia-related changes (AMLMRC) according to the 2016 World Health Organization classification and the preferred therapy for patients with AML-MRC aged 60-75 years. Materials and Methods: We retrospectively analyzed differences in clinical data among 190 patients with AML-MRC and 667 patients with AML not otherwise specified (AML-NOS). We also compared different therapeutic regimens among patients with AML-MRC aged 60-75 years. Results: Compared with AML-NOS, patients with AML-MRC had significantly different clinical characteristics as well as worse overall survival (OS) (9.2 vs. 13.6 months; p
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