Promising response to vemurafenib and cobimetinib treatment for BRAF V600E mutated craniopharyngioma: a case report and literature review
| Autor: | Nina Yu, Osama A Raslan, Han Sung Lee, Brett J Theeler, Tarek A Raafat, Ruben Fragoso, Kiarash Shahlaie, Orwa Aboud |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | CNS Oncology, Vol 13, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2045-0915 2045-0907 |
| DOI: | 10.2217/cns-2023-0018 |
| Popis: | Craniopharyngiomas are tumors that arise from the remnants of Rathke's pouch along the nasopharynx to the diencephalon. Current standard of care includes maximal surgical resection versus adjuvant radiation if a maximal resection is unfeasible. Pharmacological therapy with MAPK targeted agents is an emerging therapeutic option for tumors with BRAF V600E mutations. We report a 45-year-old male with a strictly third ventricle papillary craniopharyngioma with a BRAF V600E mutation. After initial surgery with subtotal resection, the patient demonstrated durable response to targeted BRAF and MEK inhibitor therapy with vemurafenib and cobimetinib. Our report suggests that targeted therapy may reduce the need for radiation and impact surgical interventions in select cases. |
| Databáze: | Directory of Open Access Journals |
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