Antibacterial Activity of Bisanthraquinone (+)-1,1’-Bislunatin
| Autor: | PRAPTIWI PRAPTIWI, YULIASRI JAMAL, AHMAD FATHONI, ARIF NURKANTO, ANDRIA AGUSTA |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Microbiology Indonesia, Vol 7, Iss 4 (2014) |
| Druh dokumentu: | article |
| ISSN: | 1978-3477 2087-8575 |
| DOI: | 10.5454/mi.7.4.4 |
| Popis: | Endophytic fungi has been known as a source of biologically active compunds with a broad sprectrum of activities. One of the endophytic fungi isolated from young stem of gambier plant (Uncaria gambier Roxb.:Rubiaceae), Diaporthe sp. GNBP-10, produced (+)-1,1’-bislunatin when cultivated on potato dextrose agar (PDA). (+)-1,1’-Bislunatin showed moderate antibacterial activity against 7 bacteria (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Micrococcus luteus, Shigella flexneri, Proteus vulgaris, and P. mirabilis) with MIC value in the range of 32-64 µg mL-1. The wall disruption and morphological changes in the cells affected by exposure of (+)-1,1’-bislunatin are also discussed in this article. |
| Databáze: | Directory of Open Access Journals |
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