| Autor: |
Samvel N. Sirakanyan, Domenico Spinelli, Anthi Petrou, Athina Geronikaki, Victor G. Kartsev, Elmira K. Hakobyan, Hasmik A. Yegoryan, Luca Zuppiroli, Riccardo Zuppiroli, Armen G. Ayvazyan, Ruzanna G. Paronikyan, Tatevik A. Arakelyan, Anush A. Hovakimyan |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Molecules, Vol 28, Iss 3, p 921 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1420-3049 |
| DOI: |
10.3390/molecules28030921 |
| Popis: |
The synthesis of new original bicyclic pyridine-based hybrids linked to the 1,2,3-triazole unit was described via a click reaction. The anticonvulsant activity and some psychotropic properties of the new compounds were evaluated. The biological assays demonstrated that some of the studied compounds showed high anticonvulsant and psychotropic properties. The five most active compounds (7a, d, g, j, and m) contain a pyrano [3,4-c]pyridine cycle with a methyl group in the pyridine ring in their structures. Furthermore, molecular docking studies were performed, and their results are in agreement with experimental data. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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