Observation of Glomerular Filtration Change in Chronic Hepatitis B Patients Using Tenofovir Disoproxil Fumarate

Autor: Meltem Karslıoğlu
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Van Tıp Dergisi, Vol 31, Iss 1, Pp 21-26 (2024)
Druh dokumentu: article
ISSN: 2587-0351
DOI: 10.5505/vmj.2024.44522
Popis: INTRODUCTION: This study was conducted to assess kidney function tests in outpatient individuals with a diagnosis of chronic hepatitis B who were receiving treatment with Tenofovir Disoproxil Fumarate (TDF). METHODS: Our study included patients who presented to the Infectious Diseases Polyclinic at XXX Hospital with a diagnosis of chronic hepatitis B (CHB) and were treated with Tenofovir Disoproxil Fumarate (TDF). The hospital data, available retrospectively since 2013, allowed us to examine patient follow-ups up to that year. As a result, we were able to analyze a maximum follow-up period of nine years. The study encompassed individuals over 18 years of age whose data were complete and who were regularly monitored in the outpatient clinic. RESULTS: Among the subjects, 69% (n: 69) were male, and 31% (n: 31) were female. Significant reductions in glomerular filtration rates (GFR) were observed in the 4th and 6th years compared to GFR measurements before initiating TDF treatment (p
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