| Autor: |
Cassiana Maria Garcez Ramos, Julio César Francisco, Marcia Olandoski, Katherine Athayde Teixeira de Carvalho, Ricardo Cunha, Bruna Olandoski Erbano, Lianna Ferrari Jorge, Cristina Pellegrino Baena, Vivian Ferreira do Amaral, Lucia Noronha, Rafael Michel de Macedo, José Rocha Faria-Neto, Luiz César Guarita-Souza |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Brazilian Journal of Cardiovascular Surgery, Vol 29, Iss 2, Pp 202-213 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1678-9741 |
| DOI: |
10.5935/1678-9741.20140070 |
| Popis: |
Introduction: Most cardiomyocytes do not regenerate after myocardial infarction. Porcine small intestinal submucosa has been shown to be effective in tissue repair. Objective: To evaluate myocardial tissue regeneration and functional effects of SIS implantation in pigs after left ventriculotomy. Methods: Fifteen pigs were assigned to two groups: porcine small intestinal submucosa (SIS) (N=10) and control (N=5). The SIS group underwent a mini sternotomy, left ventriculotomy and placement of a SIS patch. The control group underwent a sham procedure. Echocardiography was performed before and 60 days after the surgical procedure. Histological analysis was performed with hematoxylin-eosin stain and markers for actin 1A4, anti sarcomeric actin, connexin43 and factor VIII. Results: Weight gain was similar in both groups. Echocardiography analysis revealed no difference between groups regarding end diastolic and systolic diameters and left ventricular ejection fraction, both pre (P=0.118, P=0.313, P=0.944) and post procedure (P=0.333, P=0.522, P=0.628). Both groups showed an increase in end diastolic (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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