Exploring the utility of ultrasound to assess disuse atrophy in different muscles of the lower leg

Autor: Edward J. Hardy, Joseph J. Bass, Thomas B. Inns, Mathew Piasecki, Jessica Piasecki, Craig Sale, Robert H. Morris, Jonathan N. Lund, Ken Smith, Daniel J. Wilkinson, Philip J. Atherton, Bethan E. Phillips
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 6, Pp 2487-2496 (2024)
Druh dokumentu: article
ISSN: 2190-6009
2190-5991
DOI: 10.1002/jcsm.13583
Popis: Abstract Background Skeletal muscle is a highly plastic tissue crucial for many functions associated with whole‐body health across the life course. Magnetic resonance imaging (MRI) is the current gold standard for measuring skeletal muscle size. However, MRI is expensive, and access to facilities is often limited. B‐mode ultrasonography (U/S) has been proposed as a potential alternative to MRI for the assessment of muscle size. However, to date, no work has explored the utility of U/S to assess disuse muscle atrophy (DMA) across muscles with different atrophy susceptibility profiles, an omission which may limit the clinical application of previous work. Methods To address this significant knowledge gap, 10 young men (22 ± years, 24.1 ± 2.3 kg/m2) underwent 15‐day unilateral leg immobilization using a knee‐brace and air boot. Cross‐sectional area (CSA) and muscle thickness (MT) of the tibialis anterior (TA) and medial gastrocnemius (MG) were assessed via U/S before and after immobilization, with CSA and muscle volume assessed via MRI. Results With both muscles combined, there were good correlations between each U/S and MRI measure, both before (e.g., CSAMRI vs. MTU/S and CSAU/S: r = 0.88 and 0.94, respectively, both P
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