Cyclin D1, RET and p27 Expression in Papillary Thyroid Microcarcinoma

Autor:	Ana Barić, Vinko Marković, Davor Eterović, Vladimir Bedeković, Mirko Kontić, Ljubica Juretić Kuščić, Valdi Pešutić Pisac, Ante Punda
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	Thyroid cancer papillary [Supplementary Concept] Thyroid carcinoma anaplastic Cyclin D1 Cyclin-dependent kinase inhibitor p27 RET protein human Medicine
Zdroj:	Acta Clinica Croatica, Vol 56., Iss 1., Pp 15-20 (2017)
Druh dokumentu:	article
ISSN:	0353-9466 1333-9451 74919555
DOI:	10.20471/acc.2017.56.01.03
Popis:	The aim of the study was to determine the influence of RET, p27 and cyclin D1 on regional lymph node metastases in papillary microcarcinoma. The analysis included 70 patients with papillary thyroid microcarcinoma that underwent surgery at Split University Hospital Center between 1999 and 2001. Immunohistochemistry was performed on formalin-fixed, paraffi n-embedded tissue by the RET, p27 and cyclin D1 antibodies. Quantification was based on the intensity and distribution of nuclear staining, dividing tumors into those that showed expression (expressors) and those that showed no expression (non-expressors). Univariate analysis using χ²-test and Fisher exact test was performed with the level of statistical significance set at p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/099783ad5425420faeb8c74919555626 Zobrazit plný text záznamu View record in DOAJ