| Autor: |
Laura DiChiacchio, Avneesh K. Singh, Joshua L. Chan, Nicole M. Shockcor, Tianshu Zhang, Billeta G. Lewis, David Ayares, Philip Corcoran, Keith A. Horvath, Muhammad M. Mohiuddin |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Frontiers in Cardiovascular Medicine, Vol 6 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2297-055X |
| DOI: |
10.3389/fcvm.2019.00095 |
| Popis: |
Heterotopic cardiac xenotransplantation in the intra-abdominal position has been studied extensively in a pig-to-baboon model to define the optimal donor genetics and immunosuppressive regimen to prevent xenograft rejection. Extensive investigation using this model is a necessary stepping stone toward the development of a life-supporting animal model, with the ultimate goal of demonstrating suitability for clinical cardiac xenotransplantation trials. Aspects of surgical technique, pre- and post-operative care, graft monitoring, and minimization of infectious risk have all required refinement and optimization of heterotopic cardiac xenotransplantation over time. This review details non-immunologic obstacles relevant to this model described by our group and in the literature, as well as strategies that have been developed to address these specific challenges. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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