| Autor: |
Soichiro Hozawa, Yoshinori Haruta, Michikazu Terada, Michio Yamakido |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Allergology International, Vol 58, Iss 4, Pp 509-518 (2009) |
| Druh dokumentu: |
article |
| ISSN: |
1323-8930 |
| DOI: |
10.2332/allergolint.08-OA-0060 |
| Popis: |
Background: Whether the additive effects of the tulobuterol patch (TP), the world’s first transdermal beta2-agonist preparation, are useful in asthma patients receiving inhaled corticosteroid (ICS) is unclear. To examine the add-on effects of TP on bronchial hyperresponsiveness and reduction of the percentage of sputum eosinophils, and to compare add-on effects of TP, slow-release theophylline (SRT), and a leukotriene receptor antagonist (LTRA) in patients with asthma receiving ICS. Methods: Study 1: We randomly allocated 24 patients with asthma receiving ICS alone in equal numbers to either control treatment (ICS alone at conventional doses) or TP treatment (ICS at conventional doses plus TP at 2 mg/day). Following a 2-week observation period, patients received the allocated drug regimens for 4 weeks. Methacholine challenge test and measurement of percentage of eosinophils in hypertonic saline- induced sputum were performed before and after the treatment period. Study 2: We compared add-on effects of TP, SRT, and LTRA in 65 patients with asthma receiving ICS alone, using spirometry and peak expiratory flow (PEF). Participants in these studies had experienced decrease in morning PEF to |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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