| Autor: |
J. Peterson, L. Muddiman, F. Groves, N. Booth, W. G. Newman, J. H. McDermott, A. Mahaveer |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Frontiers in Pediatrics, Vol 12 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2296-2360 |
| DOI: |
10.3389/fped.2024.1471463 |
| Popis: |
ObjectiveNational Institute for Clinical Excellence (NICE) guidance for the management of neonatal sepsis recommends a first-line antibiotic regimen containing an aminoglycoside (gentamicin). Aminoglycoside exposure causes sensorineural hearing loss in individuals with a specific mitochondrial genetic variant (m.1555A>G). This variant can be detected promptly (in G genetic variant at risk of iatrogenic hearing loss. There needs to be integration of point-of-care genetic testing within the neonatal septic screening pathway. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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