Identification and comparison of Chlamydia psittaci, Legionella and Mycoplasma pneumonia infection

Autor: Ning Zhu, Daibing Zhou, Ruyu Yuan, Yiminniyaze Ruzetuoheti, Jing Li, Xiujuan Zhang, Shengqing Li
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: The Clinical Respiratory Journal, Vol 17, Iss 5, Pp 384-393 (2023)
Druh dokumentu: article
ISSN: 1752-699X
1752-6981
DOI: 10.1111/crj.13603
Popis: Abstract Introduction Conventional etiological detection and pathogenic antibody methods make it challenging to identify the atypical pathogens among the community‐acquired pneumonia (CAP). Metagenomic next‐generation sequencing (mNGS) could rapidly detect all potentially infectious diseases and identifies novel or potential pathogens. Methods Eighteen patients diagnosed with atypical CAP were enrolled in this retrospective study, including nine Chlamydia psittaci pneumonia (C. p), four Legionella pneumonia (L. p) and five Mycoplasma pneumonia (M. p). We simultaneously tested bronchoalveolar lavage fluid (BALF) samples for conventional microbiological methods and mNGS, and blood specimens were analysed. We also collected and compared baseline and clinical characteristics and treatment responses. Results Patients with C. p and L. p had similar symptoms, including fever, cough, headache, dyspnoea, asthenia, shivering and headache, compared with M. p, whose symptoms were slight. C. p and L. p usually showed multiple lobar distributions with pleural effusion. Serologic testing indicated that L. p had higher levels of white blood cells (WBCs), neutrophils, C‐reactive protein (CRP), procalcitonin (PCT), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and creatinine compared with M. p and L. p (p
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