Bisphenol a increases risk for presumed non-alcoholic fatty liver disease in Hispanic adolescents in NHANES 2003–2010

Autor:	Sofia G. Verstraete, Janet M. Wojcicki, Emily R. Perito, Philip Rosenthal
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	NAFLD BPA Insulin resistance Obesity National Health and Nutrition Examination Survey Industrial medicine. Industrial hygiene RC963-969 Public aspects of medicine RA1-1270
Zdroj:	Environmental Health, Vol 17, Iss 1, Pp 1-8 (2018)
Druh dokumentu:	article
ISSN:	1476-069X
DOI:	10.1186/s12940-018-0356-3
Popis:	Abstract Background Bisphenol-A (BPA) is a ubiquitous chemical and recognized endocrine disruptor associated with obesity and related disorders. We explored the association between BPA levels and suspected non-alcoholic fatty liver disease (NAFLD). Methods Unweighted analyses were used to study the relationship between urinary BPA levels and suspected NAFLD (alanine aminotransferase (ALT). > 30 U/L, body mass index (BMI) Z-score > 1.064 and evidence of insulin resistance) using National Health and Nutrition Examination Survey (NHANES) data (2003–2010) on 12–19 year olds. Unweighted and weighted analyses were used to evaluate the risk with only elevated ALT. Results We included 944 adolescents with urinary BPA and fasting laboratory tests from a total of 7168 adolescents. Risk of suspected NAFLD was increased in the second quartile of BPA levels (1.4–2.7 ng/mL) when compared to the first (
Databáze:	Directory of Open Access Journals
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