Sphingosine-1-phosphate receptor 3 in the medial prefrontal cortex promotes stress resilience by reducing inflammatory processes

Autor: Brian F. Corbett, Sandra Luz, Jay Arner, Jiah Pearson-Leary, Abhishek Sengupta, Deanne Taylor, Philip Gehrman, Richard Ross, Seema Bhatnagar
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-10904-8
Popis: S1PR3 is a G protein coupled receptor, that has a role in inflammation. Here the authors show that in the CNS, S1PR3 may contribute to resilience to stressful experiences; resilient rodents show elevated S1pr3, and knockdown results in greater susceptibility to stress.
Databáze: Directory of Open Access Journals