Transcription factors AP-2α and AP-2β regulate distinct segments of the distal nephron in the mammalian kidney

Autor: Joseph O. Lamontagne, Hui Zhang, Alia M. Zeid, Karin Strittmatter, Alicia D. Rocha, Trevor Williams, Sheryl Zhang, Alexander G. Marneros
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-29644-3
Popis: How the distal nephron is patterned during kidney development has been difficult to study. Here they show that AP-2β is required for the formation and postnatal function of distal convoluted tubules, whereas AP-2α has a role in maintaining the structure of medullary collecting ducts.
Databáze: Directory of Open Access Journals