Phenolate‐Induced N−O Bond Formation versus Tiemann‐Type Rearrangement for the Synthesis of 3‐Aminobenzisoxazoles and 2‐Aminobenzoxazoles

Autor:	Benedikt Hufnagel, W. Felix Zhu, Hanna M. Franz, Prof. Dr. Ewgenij Proschak, Dr. Victor Hernandez‐Olmos
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	3-aminobenzisoxazoles 2-aminobenzoxazoles nitrenoid precursors oxadiazolone Tiemann rearrangement Chemistry QD1-999
Zdroj:	ChemistryOpen, Vol 11, Iss 12, Pp n/a-n/a (2022)
Druh dokumentu:	article
ISSN:	2191-1363
DOI:	10.1002/open.202200252
Popis:	Abstract A novel oxadiazolone‐based method for the synthesis of 3‐aminobenzisoxazoles by N−O bond formation and of 2‐aminobenzoxazoles through a Tiemann‐type rearrangement has been developed. The synthesis of these two pharmaceutically relevant heterocycles was realized by an unexplored retrosynthetic disconnection using a cyclic nitrenoid precursor‐based strategy. The selective formation of the two isomers was significantly influenced by steric and electronic effects of substituents. However, tetrabutylammonium chloride (TBACl) efficiently promoted the Tiemann‐type rearrangement over N−O bond formation. Control experiments indicate that deprotonation of the phenol induces both rearrangements.
Databáze:	Directory of Open Access Journals
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