Acyl CoA binding protein (ACBP): an autophagy checkpoint that can be targeted for improving cancer immunosurveillance

Autor:	Léa Montégut, Isabelle Martins, Guido Kroemer
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Caloric restriction mimetics chemotherapy immune checkpoint inhibitor immunotherapy mammary carcinoma non-small cell lung cancer Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	OncoImmunology, Vol 13, Iss 1 (2024)
Druh dokumentu:	article
ISSN:	2162402X 2162-402X
DOI:	10.1080/2162402X.2024.2413200
Popis:	Acyl CoA binding protein (ACBP) encoded by DBI is a tissue hormone that limits autophagy in multiple cell types, hence acting as an extracellular autophagy checkpoint. We recently reported in Molecular Cancer that monoclonal antibodies neutralizing ACBP improve immunosurveillance of breast and lung carcinomas. Moreover, ACBP neutralization improves the outcome of neoadjuvant chemoimmunotherapy with PD-1 blockade in preclinical models.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/a09535f849e24af8a4bb78fb65c7838b Zobrazit plný text záznamu View record in DOAJ