| Autor: |
Zixing Zhou, Lijun Wang, Zihao Wen, Shaoling Zheng, Xiaohong Ye, Dandan Liu, Jing Wu, Xiaoqian Zou, Yumei Liu, Yao Wang, Shirui Dong, Xiuxia Huang, Xiuben Du, Kehui Zhu, Xiaojing Chen, Shiqi Huang, Chengli Zeng, Yajing Han, Baohuan Zhang, Lihong Nie, Guang Yang, Chunxia Jing |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Frontiers in Endocrinology, Vol 9 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1664-2392 |
| DOI: |
10.3389/fendo.2018.00709 |
| Popis: |
Objective: To explore the association between the methylation levels in the promoter regions of the NLRP3, AIM2, and ASC genes and T2DM and its vascular complications in a Southern Han Chinese population and further analyze their interaction and mediating effects with environmental factors in T2DM.Methods: A case-control study was used to determine the association between population characteristics, the methylation level in the promoter region of the NLRP3, AIM2, and ASC genes and T2DM and vascular complications. A mediating effect among genes-environment-T2DM and the interaction of gene-gene or gene-environment factors was explored.Results: In the logistic regression model with adjusted covariants, healthy people with lower total methylation levels in the AIM2 promoter region exhibited a 2.29-fold [OR: 2.29 (1.28~6.66), P = 0.011] increased risk of developing T2DM compared with higher-methylation individuals. T2DM patients without any vascular complications who had lower methylation levels ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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