Formulation and kinetic modeling of curcumin loaded intranasal mucoadhesive microemulsion

Autor:	B Mikesh Patel, Surjyanarayan Mandal, K S Rajesh
Jazyk:	angličtina
Rok vydání:	2012
Předmět:	Curcumin intranasal mucoadhesive microemulsion Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
Zdroj:	Journal of Pharmacy and Bioallied Sciences, Vol 4, Iss 5, Pp 81-83 (2012)
Druh dokumentu:	article
ISSN:	0975-7406 0976-4879
DOI:	10.4103/0975-7406.94148
Popis:	It is a challenge to develop the optimum dosage form of poorly water-soluble drugs and to target them due to limited bioavailability, intra and inter subject variability. In this investigation, mucoadhesive microemulsion of curcumin was developed by water titration method taking biocompatible components for intranasal delivery and was characterized. Nasal ciliotoxicity studies were carried out using excised sheep nasal mucosa. in vitro release studies of formulations and PDS were performed. Labrafil M 1944 CS based microemulsion was transparent, stable and nasal non-ciliotoxic having particle size 12.32±0.81nm (PdI=0.223) and from kinetic modeling, the release was found to be Fickian diffusion for mucoadhesive microemulsion.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/09467bfe45cf4081ac5d88a274ae4044 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF