Monascin and ankaflavin prevents metabolic disorder by blood glucose regulatory, hypolipidemic, and anti-inflammatory effects in high fructose and high fat diet-induced hyperglycemic rat

Autor: Che-Wei Lin, Chun-Hung Lin, Ya-Wen Hsu, Tzu-Ming Pan, Chun-Lin Lee
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Functional Foods, Vol 104, Iss , Pp 105537- (2023)
Druh dokumentu: article
ISSN: 1756-4646
DOI: 10.1016/j.jff.2023.105537
Popis: Monascin (MS) and ankaflavin (AK) produced by Monascus purpureus fermented red mold dioscorea (RMD) elicit an anti-diabetes effect in streptozocin-induced type 1 diabetes. However, their effects on preventing metabolic disorder with type 2 diabetes induced by long-term high fat and high fructose diet (HFFD) remain unclear. In this study, RMD, MS, and AK were orally administered to HFFD-fed rats for 10 weeks. The result showed that orally administered MS, AK, and RMD were able to prevent the develop-ment. MS had a more potent effect on lowering blood glucose, fructosamine, and insulin resistance, and increasing hepatic glucose transporters-2, adipocyte glucose transporters-4, and hypoxia-inducible factor 1-α. AK had a greater effect on lowering blood lipid, adipose pad, and adipose inflammatory factors (interlukin-1β, tumor necrosis factor-α, and interlukin-6) levels. Therefore, the prevention of type 2 diabetes and metabolic disorders of RMD could be mainly attributed to the synergistic effect of MS and AK.
Databáze: Directory of Open Access Journals
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