Identification of metabolic syndrome using lipid accumulation product and cardiometabolic index based on NHANES data from 2005 to 2018

Autor: Xiaojie Chen, Yifan Zhao, Jihong Sun, Yaohui Jiang, Yi Tang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Nutrition & Metabolism, Vol 21, Iss 1, Pp 1-16 (2024)
Druh dokumentu: article
ISSN: 1743-7075
DOI: 10.1186/s12986-024-00864-2
Popis: Abstract Background Numerous studies indicate that visceral adipose tissue (VAT) significantly contribute to metabolic syndrome (MetS) development. This study aims to assess the distinguishing value of novel obesity markers, specifically lipid accumulation products (LAP) and cardiometabolic index (CMI), in relation to MetS. Considering the gender disparity in MetS prevalence, it is essential to explore whether LAP and CMI exhibit differential distinguishing capabilities by gender. Method The investigation included a total of 11,687 qualified individuals who participated in the NHANES survey spanning a 14-year period from 2005 to 2018. Biochemical analysis of blood and body measurements were utilized to determine LAP and CMI values for each participant. Inclusion of gender as a variable was a key factor in the examination of all data. Restricted cube plots (RCS) were utilized to analyze the strength of the relationship between LAP, CMI, and MetS. The study delved into potential connections between LAP and CMI with MetS, all-cause and cardiovascular mortality using various statistical models such as multivariate logistic regression and Cox regression. Results The findings revealed a significant nonlinear association between CMI, LAP, and MetS (P-non-linear 0.005) MetS. Impressively, LAP and CMI were identified as the primary predictors of MetS in both genders from AUC (P
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