Platelet antibodies in immune thrombocytopenia and related conditions

Autor:	Kiefel Volker
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	alloimmunization drug-induced immune thrombocytopenia fetal and neonatal alloimmune thrombocytopenia immune thrombocytopenia immunoassay platelet antibody post-transfusion purpura transfusion reaction Medical technology R855-855.5
Zdroj:	Journal of Laboratory Medicine, Vol 44, Iss 5, Pp 273-284 (2020)
Druh dokumentu:	article
ISSN:	2567-9430 2567-9449
DOI:	10.1515/labmed-2020-0012
Popis:	Platelet autoantibodies are a common finding in immune thrombocytopenia (ITP) and in rare cases of antibody-mediated platelet function (“acquired thrombasthenia”). In drug-induced immune thrombocytopenia, antibodies react with platelets only in the presence of the offending drug. Alloantibodies reacting with platelets are induced by transfusion of cellular blood products or during pregnancy. They are responsible for fetal/neonatal alloimmune thrombocytopenia (FNAIT), they are able to cause febrile, nonhemolytic transfusion reactions and they give rise to insufficient platelet increments following platelet transfusions. Two rare transfusion reactions: post-transfusion purpura (PTP) and passive alloimmune thrombocytopenia (PAT) are triggered by platelet alloantibodies. This review discusses the clinical value of tests for platelet antibodies in various clinical situations related to insufficient primary hemostasis.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/093234e23f7347ea915cd529f756347b Zobrazit plný text záznamu View record in DOAJ