| Autor: |
Tanja Fererberger, Christa Buechler, Arne Kandulski, Tanja Elger, Johanna Loibl, Stephan Schmid, Stefanie Sommersberger, Stefan Gunawan, Sebastian Zundler, Muriel Huss, Dominik Bettenworth, Sally Kempa, Simon Weidlich, Bandik Föh, Xinyu Huang, Marcin Grzegorzek, Stefanie Derer-Petersen, Ulrich L. Günther, Jens U. Marquardt, Claudia Kunst, Karsten Gülow, Martina Müller, Christian Sina, Franziska Schmelter, Hauke C. Tews |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Frontiers in Medicine, Vol 11 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2296-858X |
| DOI: |
10.3389/fmed.2024.1334865 |
| Popis: |
IntoductionIdentification of specific metabolome and lipidome profile of patients with primary sclerosing cholangitis (PSC) is crucial for diagnosis, targeted personalized therapy, and more accurate risk stratification.MethodsNuclear magnetic resonance (NMR) spectroscopy revealed an altered metabolome and lipidome of 33 patients with PSC [24 patients with inflammatory bowel disease (IBD) and 9 patients without IBD] compared with 40 age-, sex-, and body mass index (BMI)-matched healthy controls (HC) as well as 64 patients with IBD and other extraintestinal manifestations (EIM) but without PSC.ResultsIn particular, higher concentrations of pyruvic acid and several lipoprotein subfractions were measured in PSC in comparison to HC. Of clinical relevance, a specific amino acid and lipid profile was determined in PSC compared with IBD and other EIM.DiscussionThese results have the potential to improve diagnosis by differentiating PSC patients from HC and those with IBD and EIM. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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