Comparison of Eradication Rates Using Standard Triple Therapy and Sequential Therapy

Autor: Yuri Kim, Ji Yong Ahn, Hwoon-Yong Jung, Jin Hee Noh, Hee Kyong Na, Kee Wook Jung, Jeong Hoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee
Jazyk: English<br />Korean
Rok vydání: 2023
Předmět:
Zdroj: The Korean Journal of Helicobacter and Upper Gastrointestinal Research, Vol 23, Iss 4, Pp 277-282 (2023)
Druh dokumentu: article
ISSN: 1738-3331
DOI: 10.7704/kjhugr.2023.0042
Popis: Objectives The incidence of treatment failures following standard triple therapy (STT) for Helicobacter pylori eradication (HPE) has reached an unacceptable level. Sequential therapy (SQ) has emerged as a promising approach to counteract the escalation of antibiotic resistance. In this study, we used a chronological cohort dataset to conduct a comparative analysis of the eradication rates, compliance, and adverse events associated with the 7-day STT and SQ. Methods A total of 789 patients underwent HPE treatment at Asan Medical Center between July 2013 and August 2017. Among them, 378 received a 7-day STT and 411 received a 10-day SQ. Baseline clinical data and treatment parameters were compared between the two treatment groups. Results SQ demonstrated an eradication rate of 84.7% (348/411), which was superior to that of the 7-day STT (74.1%; p
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