| Autor: |
Hristo S. Milev, Vasil Nanev, Desislava Dimitrova, Strahil Strashilov, Angel Yordanov, Miroslava Mihailova-Strashilova, Silvia Naneva, Simoneta Ivanova, Milena Karcheva, Ivan Ivanov |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Journal of Biomedical & Clinical Research, Vol 17, Iss 1, Pp 53-58 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1313-9053 |
| DOI: |
10.3897/jbcr.e126709 |
| Popis: |
There are no specific recommendations for evaluating the Ki-67 index in heterogeneous breast carcinomas. This study aimed to evaluate the applicability of currently accepted recommendations for Ki-67 evaluation in breast cancer in the context of intratumor heterogeneity. Twelve cases of heterogeneous breast carcinomas obtained from 110 patients were retrospectively studied. Ki-67 staining was performed according to protocols provided by the reagent manufacturer. Results for Ki-67 of the separate components in each tumor were obtained, described, and analyzed statistically using a paired t-test. Values of p < 0.05 were considered as statistically significant. SPSS software was used for statistical analysis. Results from the comparison of the Ki-67 index evaluation in each heterogeneous component of the studied tumors demonstrated no statistically significant difference of mean values t = 0.4802, p = 0.6405. The anticipation of an average Ki-67 score in the evaluated cases would have changed the molecular subtype from Luminal B to Luminal A (due to the Ki-67 index below 14%) in two of the cases. Heterogeneous tumors had a different Ki-67 index in their separate components. Our observations suggest that Ki-67 in heterogeneous breast carcinoma is evaluated and reported separately for the distinguishable tumor components. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
