Differences in airway lumen area between supine and upright computed tomography in patients with chronic obstructive pulmonary disease

Autor: Shotaro Chubachi, Yoshitake Yamada, Minoru Yamada, Yoichi Yokoyama, Akiko Tanabe, Shiho Matsuoka, Yuki Niijima, Wakako Yamasawa, Hidehiro Irie, Mitsuru Murata, Koichi Fukunaga, Masahiro Jinzaki
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Respiratory Research, Vol 22, Iss 1, Pp 1-9 (2021)
Druh dokumentu: article
ISSN: 1465-993X
DOI: 10.1186/s12931-021-01692-1
Popis: Abstract Background No clinical studies to date have compared the inspiratory and expiratory airway lumen area between supine and standing positions. Thus, the aims of this study were twofold: (1) to compare inspiratory and expiratory airway lumen area (IAA and EAA, respectively) on computed tomography (CT) among supine and standing positions; and (2) to investigate if IAA and EAA are associated with lung function abnormality in patients with chronic obstructive pulmonary disease (COPD). Methods Forty-eight patients with COPD underwent both low-dose conventional (supine position) and upright CT (standing position) during inspiration and expiration breath-holds and a pulmonary function test (PFT) on the same day. We measured the IAA and EAA in each position. Results For the trachea to the third-generation bronchi, the IAA was significantly larger in the standing position than in the supine position (4.1–4.9% increase, all p
Databáze: Directory of Open Access Journals
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