| Autor: |
David C. Schöndorf, Myriam Elschami, Maximilian Schieck, Ebru Ercan-Herbst, Christian Weber, Yasmin Riesinger, Sara Kalman, Doris Steinemann, Dagmar E. Ehrnhoefer |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Stem Cell Research, Vol 34, Iss , Pp - (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1873-5061 |
| DOI: |
10.1016/j.scr.2018.11.012 |
| Popis: |
Alzheimer's Disease (AD) is the major cause of dementia in the elderly, and cortical neurons differentiated from patient-derived induced pluripotent stem cells (iPSCs) can recapitulate disease phenotypes such as tau phosphorylation or amyloid beta (Aß) deposition. Here we describe the generation of an iPSC cohort consisting of 2 sporadic AD cases and 3 controls, derived from dermal fibroblasts. All lines were karyotypically normal, showed expression of stem cell markers and efficiently differentiated into cells of all three germ layers. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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