Regulation of skeletal muscle GLUT-4 expression by exercise and nutritional stimuli
| Autor: | Kazuhiko Higashida, Izumi Tabata, Mitsuru Higuchi, Shin Terada |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Journal of Physical Fitness and Sports Medicine, Vol 2, Iss 3, Pp 355-360 (2013) |
| Druh dokumentu: | article |
| ISSN: | 2186-8131 2186-8123 |
| DOI: | 10.7600/jpfsm.2.355 |
| Popis: | Skeletal muscle is the primary site of glucose uptake in humans. Glucose transport activity, which is the rate-limiting step in muscle glucose metabolism, is linearly related to the content of the GLUT-4 isoform of the glucose transporter. Therefore, the level of GLUT-4 in skeletal muscle may be an important determinant of whole-body glucose disposal. It has been well documented that long-term, low- to moderate-intensity endurance exercise training induces an increase in muscle GLUT-4 content. However, emerging evidence suggests that an adaptive increase in GLUT-4 occurs even after a single acute bout of exercise or high-intensity intermittent exercise training. Recent findings also indicate that nutritional status affects GLUT-4 expression in skeletal muscle. This review provides an overview of the effects of exercise and nutritional status on GLUT-4 content in skeletal muscle, and summarizes recent progress in elucidating the molecular regulation of muscle GLUT-4 gene expression by exercise and nutritional stimuli. |
| Databáze: | Directory of Open Access Journals |
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