The role of sclerostin and PGC-1 alpha in the pathogenesis of osteoporosis
| Autor: | Armine V. GRIGORYAN, Tatyana M. BETOVA, Theresa B. DINEVA, Savelina L. POPOVSKA, Radoslav G. TRIFONOV, Aneliya A. DIMITROVA |
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| Jazyk: | English<br />French |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Archives of the Balkan Medical Union, Vol 55, Iss 2, Pp 284-289 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1584-9244 2558-815X |
| DOI: | 10.31688/ABMU.2020.55.2.11 |
| Popis: | Introduction. Canonical Wnt signaling pathway regulates stromal stem cells (SSCs) differentiation and controls the balance between adipogenesis and osteogenesis. Estrogen deficiency affects Wnt signaling by altering the expression of sclerostin (SCL) and the peroxisome proliferator-activated receptor-∝ coactivator 1-∝(PGC-1∝) in the bone tissue. The objective of the study was to monitor whether there is a feedback mechanism between SCL and PGC-1∝ and to determine the extent of the immunohistochemical staining of PGC-1∝ and SCL in bone tissue of estrogen deficiency-induced osteoporosis in female Wistar rats. Materials and methods. An experiment was performed on 20 female Wistar rats at reproductive age (2 months), divided into 2 groups: in group 1 (G1) 10 animals were ovariectomized (ovx) and in group 2 (G2) 10 of the remaining were sham-operated (sham). Results. We found that the PGC-1∝ in the bone marrow stromal cells was reduced in the group with osteoporosis (G1 – ovariectomized rats), compared to sham-operated control group G2 (p |
| Databáze: | Directory of Open Access Journals |
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