Tolerogenic dendritic cell reporting: Has a minimum information model made a difference?
| Autor: | Ayesha Sahar, Ioana Nicorescu, Gabrielle Barran, Megan Paterson, Catharien M.U. Hilkens, Phillip Lord |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | PeerJ, Vol 11, p e15352 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2167-8359 80569471 |
| DOI: | 10.7717/peerj.15352 |
| Popis: | Minimum information models are reporting frameworks that describe the essential information that needs to be provided in a publication, so that the work can be repeated or compared to other work. In 2016, Minimum Information about Tolerogenic Antigen-Presenting cells (MITAP) was created to standardize the reporting on tolerogenic antigen-presenting cells, including tolerogenic dendritic cells (tolDCs). tolDCs is a generic term for dendritic cells that have the ability to (re-)establish immune tolerance; they have been developed as a cell therapy for autoimmune diseases or for the prevention of transplant rejection. Because protocols to generate these therapeutic cells vary widely, MITAP was deemed to be a pivotal reporting tool by and for the tolDC community. In this paper, we explored the impact that MITAP has had on the tolDC field. We did this by examining a subset of the available literature on tolDCs. Our analysis shows that MITAP is used in only the minority of relevant papers (14%), but where it is used the amount of metadata available is slightly increased over where it is not. From this, we conclude that MITAP has been a partial success, but that much more needs to be done if standardized reporting is to become common within the discipline. |
| Databáze: | Directory of Open Access Journals |
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