| Autor: |
Michael R. Filbin, Arnav Mehta, Alexis M. Schneider, Kyle R. Kays, Jamey R. Guess, Matteo Gentili, Bánk G. Fenyves, Nicole C. Charland, Anna L.K. Gonye, Irena Gushterova, Hargun K. Khanna, Thomas J. LaSalle, Kendall M. Lavin-Parsons, Brendan M. Lilley, Carl L. Lodenstein, Kasidet Manakongtreecheep, Justin D. Margolin, Brenna N. McKaig, Maricarmen Rojas-Lopez, Brian C. Russo, Nihaarika Sharma, Jessica Tantivit, Molly F. Thomas, Robert E. Gerszten, Graham S. Heimberg, Paul J. Hoover, David J. Lieb, Brian Lin, Debby Ngo, Karin Pelka, Miguel Reyes, Christopher S. Smillie, Avinash Waghray, Thomas E. Wood, Amanda S. Zajac, Lori L. Jennings, Ida Grundberg, Roby P. Bhattacharyya, Blair Alden Parry, Alexandra-Chloé Villani, Moshe Sade-Feldman, Nir Hacohen, Marcia B. Goldberg |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Cell Reports Medicine, Vol 2, Iss 5, Pp 100287- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2666-3791 |
| DOI: |
10.1016/j.xcrm.2021.100287 |
| Popis: |
Summary: Mechanisms underlying severe coronavirus disease 2019 (COVID-19) disease remain poorly understood. We analyze several thousand plasma proteins longitudinally in 306 COVID-19 patients and 78 symptomatic controls, uncovering immune and non-immune proteins linked to COVID-19. Deconvolution of our plasma proteome data using published scRNA-seq datasets reveals contributions from circulating immune and tissue cells. Sixteen percent of patients display reduced inflammation yet comparably poor outcomes. Comparison of patients who died to severely ill survivors identifies dynamic immune-cell-derived and tissue-associated proteins associated with survival, including exocrine pancreatic proteases. Using derived tissue-specific and cell-type-specific intracellular death signatures, cellular angiotensin-converting enzyme 2 (ACE2) expression, and our data, we infer whether organ damage resulted from direct or indirect effects of infection. We propose a model in which interactions among myeloid, epithelial, and T cells drive tissue damage. These datasets provide important insights and a rich resource for analysis of mechanisms of severe COVID-19 disease. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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