Biomimetic catalytic transformation of toxic α-oxoaldehydes to high-value chiral α-hydroxythioesters using artificial glyoxalase I

Autor: Sang Yeon Park, In-Soo Hwang, Hyun-Ju Lee, Choong Eui Song
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms14877
Popis: Glyoxalase I converts toxic methylglyoxal to a thioester. Here the authors report a synthetic analogue capable of enantioselectively converting alpha-keto aldehydes to thioesters via formation of a hemithioacetal, giving access to both enantiomers of a range of alpha-hydroxy thioesters.
Databáze: Directory of Open Access Journals