Unravelling the mosaic: Epigenetic diversity in glioblastoma
| Autor: | Sara Lucchini, Myrianni Constantinou, Silvia Marino |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Molecular Oncology, Vol 18, Iss 12, Pp 2871-2889 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1878-0261 1574-7891 15712494 |
| DOI: | 10.1002/1878-0261.13706 |
| Popis: | Glioblastoma is the most common primary malignant brain tumour. Despite decades of intensive research in the disease, its prognosis remains poor, with an average survival of only 14 months after diagnosis. The remarkable level of intra‐ and interpatient heterogeneity is certainly contributing to the lack of progress in tackling this tumour. Epigenetic dysregulation plays an important role in glioblastoma biology and significantly contributes to intratumour heterogeneity. However, it is becoming increasingly clear that it also contributes to intertumour heterogeneity, which historically had mainly been linked to diverse genetic events occurring in different patients. In this review, we explore how DNA methylation, chromatin remodelling, microRNA (miRNA) dysregulation, and long noncoding RNA (lncRNA) alterations contribute to intertumour heterogeneity in glioblastoma, including its implications for advanced tumour stratification, which is the essential first step for developing more effective patient‐specific therapeutic approaches. |
| Databáze: | Directory of Open Access Journals |
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