| Autor: |
Xiangwei Wang, Liqun Yang, Jeong-Hyeon Choi, Eiko Kitamura, Chang-Sheng Chang, Jane Ding, Eun J. Lee, Hongjuan Cui, Han-Fei Ding |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Genomics Data, Vol 2, Iss C, Pp 50-52 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
2213-5960 |
| DOI: |
10.1016/j.gdata.2014.04.002 |
| Popis: |
Induction of differentiation is a therapeutic strategy in neuroblastoma, a common pediatric cancer of the sympathetic nervous system. The homeobox protein HOXC9 is a key regulator of neuroblastoma differentiation. To gain a molecular understanding of the function of HOXC9 in promoting differentiation of neuroblastoma cells, we conducted a genome-wide analysis of the HOXC9-induced differentiation program by microarray gene expression profiling and chromatin immunoprecipitation in combination with massively parallel sequencing (ChIP-seq). Here we describe in detail the experimental system, methods, and quality control for the generation of the microarray and ChIP-seq data associated with our recent publication [1]. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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