| Autor: |
Kacper Toczyłowski, Joanna Łasecka-Zadrożna, Ilona Pałyga-Bysiecka, Kamila Maria Ludwikowska, Magdalena Okarska-Napierała, Natalia Dudek, Aneta Afelt, Catherine Suski, Miron Bartosz Kursa, Teresa Jackowska, Ernest Kuchar, Leszek Szenborn, Katarzyna Mazur-Melewska, Marta Barszcz, Elżbieta BerdejSzczot, Sebastian Brzuszkiewicz, Piotr Buda, Alicja Czajka, Agnieszka Czech, Ewa Czerwińska, Magdalena Figlerowicz, Małgorzata FirekPędras, Aneta Gawlik, Ewelina Gowin, Olga Izdebska, Danuta JanuszkiewiczLewandowska, Justyna Kiepuszka, Agnieszka Koczwara, Danuta Koszałko, Magdalena KośmiderŻurawska, Janusz Książyk, Beata Kucińska, Martyna Kukawska, Anita Lackowska, Katarzyna Łapacz, Agnieszka Maliszak, Anna Mania, Joanna Mańdziuk, Artur Mazur, Cezary Niszczota, Paulina OpalińskaZielonka, Katarzyna Rojewska, Anna RożnowskaWójtowicz, Bartosz Siewert, Paulina Sobiczewska, Lidia Stopyra, Agnieszka StrobaŻelek, Joanna StryczyńskaKazubska, Tomasz Szatkowski, Barbara Szczepańska, Maciej Szczukocki, Robert Szylo, Filip Tyc, Katarzyna Wielgos, Ewa Wołowska, Jacek Wysocki, Anna Zacharzewska, Marcin Zaniew, Marzena Zielińska, Katarzyna ZiębaGlonek |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
International Journal of Infectious Diseases, Vol 122, Iss , Pp 703-709 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1201-9712 |
| DOI: |
10.1016/j.ijid.2022.07.021 |
| Popis: |
Objectives: Multisystem inflammatory syndrome in children (MIS-C) is the result of an immune response triggered by a previous exposure to SARS-CoV-2. The clinical presentation of MIS-C overlaps with other life-threatening bacterial infections, in which antimicrobials are the mainstay therapy. The aim of study was to describe the use of antibiotics in children with MIS-C in Poland. Methods: The analysis of 345 children reported from 42 Polish cities to the national MultiOrgan Inflammatory Syndromes COVID-19 Related Study (MOIS-CoR Study) from June 2020 to April 2021. Results: At least one antibiotic was used in 310 (90%) children, mainly third-generation cephalosporin (251/310). Broad-spectrum antibiotics were used in 258 (75%) children and 224 (87%) received this treatment for more than 3 days. Concentrations of serum procalcitonin >2 µg/l and the presence of lower respiratory symptoms were associated with increased odds of receiving any antibiotic. Conclusion: Although bacterial infections in patients with MIS-C are uncommon, we show that MIS-C poses a challenge to clinicians who are faced with the decision to start, continue, or stop antimicrobial therapy. Antibiotic stewardship in patients with MIS-C should be improved to ensure that likely pathogens are treated and that antimicrobials are stopped when bacterial infections are excluded and the diagnosis of MIS-C is made. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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