Potential role of soluble TNF-α receptors in diagnosis of idiopathic membranous nephropathy

Autor: Chunhua Xun, Yong Zhao, Wenjuan Wang, Tiantian Cheng
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: European Journal of Inflammation, Vol 16 (2018)
Druh dokumentu: article
ISSN: 2058-7392
20587392
DOI: 10.1177/2058739218776081
Popis: Soluble tumor necrosis factor alpha (TNF-α) receptors contain two receptors: soluble tumor necrosis factor receptor (sTNFR) 1 and 2, and the aim of our study was to discover their concentration and diagnostic value for idiopathic membranous nephropathy (IMN). In total, 58 patients with IMN, 51 patients with chronic kidney disease (CKD), and 30 healthy volunteers were enrolled in this study. Levels of serum sTNFR1 and sTNFR2 were determined by enzyme-linked immunosorbent assay (ELISA). Serum cystatin C (CysC), urea, creatinine (CREA), uric acid (UA), total protein (TP), albumin (ALB), and 24-h urinary protein (proteinuria, PRO) were examined by automatic biochemical analyzer. Levels of sTNFR1 and sTNFR2 were significantly higher in IMN group than CKD and control group ( P
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