| Autor: |
Karen Simmer, Sanjay Patole, Shripada Rao, Trevor A Mori, Elizabeth McKinnon, Kwi Moon, Kevin Croft |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
BMJ Paediatrics Open, Vol 8, Iss 1 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2399-9772 |
| DOI: |
10.1136/bmjpo-2024-002579 |
| Popis: |
Background There is limited evidence regarding the optimal time to commence parenteral nutrition (PN) in term and late preterm infants.Design Single-centre, non-blinded, exploratory randomised controlled trial.Setting A level-3 neonatal unit in a stand-alone paediatric hospital.Patients Infants born ≥34 weeks of gestation and ≤28 days, who needed PN. Eligible infants were randomised on day 1 or day 2 of admission.Interventions Early (day 1 or day 2 of admission, N=30) or late (day 6 of admission, N=30) PN.Main outcome measures Plasma phenylalanine and F2-isoprostane levels on day 4 and day 8 of admission. Secondary outcomes were amino-acid and fatty-acid profiles on day 4 and day 8, and clinical outcomes.Results The postnatal age at randomisation was similar between the groups (2.3 (SD 0.8) vs 2.3 (0.7) days, p=0.90). On day 4, phenylalanine levels in early-PN infants were higher than in late-PN (mean (SD) 62.9 (26.7) vs 45.5 (15.3) µmol/L; baseline-adjusted percentage difference 25.8% (95% CI 11.6% to 39.9%), p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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