| Autor: |
Edson Holanda Teixeira, Maria Olívia Pereira, Mariana Henriques, Benildo Sousa Cavada, Maria Rose Jane Ribeiro Albuquerque, Paulo Nogueira Bandeira, Francisco Vassiliepe Sousa Arruda, Hélcio Silva dos Santos, Victor Alves Carneiro |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Molecules, Vol 16, Iss 1, Pp 190-201 (2010) |
| Druh dokumentu: |
article |
| ISSN: |
1420-3049 |
| DOI: |
10.3390/molecules16010190 |
| Popis: |
Croton nepetaefolius is a native plant from northeastern Brazil that belongs to the Euphorbiaceae family. The biological action of this plant has been extensively explored, being the secondary metabolites responsible for its properties alkaloids, diterpenes, and triterpenes. This study aimed to evaluate the ability of casbane diterpene (CD), isolated from the ethanolic extract of C. nepetaefolius, to inhibit microbial growth and biofilm formation of several clinical relevant species (bacteria and yeasts). It was found that CD possessed biocidal and biostatic activity against the majority of the species screened, with minimal active concentrations ranging between 125 and 500 µg/mL. In addition, it was observed that biofilm formation was inhibited even when the planktonic growth was not significantly affected. In conclusion, CD showed potential to be a natural tool for the treatment of diseases caused by different infectious microorganisms. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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