Physicochemical stability of Cabazitaxel Zentiva® solution in vials after opening and diluted solutions in three infusion bags
| Autor: | D’Huart Elise, Sacrez Matthieu, Vigneron Jean, Sobalak Nathalie, Demoré Béatrice |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Pharmaceutical Technology in Hospital Pharmacy, Vol 8, Iss 1, Pp 260-6 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2365-2411 2365-242X |
| DOI: | 10.1515/pthp-2022-0009 |
| Popis: | To the best of our knowledge, few studies have been published on the stability of cabazitaxel in infusion bags. Stabilis® database has selected a study demonstrating the stability of this molecule at 0.15 mg/mL for 28 days at 4 °C and 25 °C in polyolefin bags. The aim of this work was to study the physicochemical stability of Cabazitaxel Zentiva® solutions in vials after “opening” with a vented ChemoClave® Spike, at 25 °C, protected from light and in solutions diluted at 0.1 and 0.26 mg/mL in 0.9 % sodium chloride (0.9 % NaCl) or dextrose 5 % (D5W) in 3 types of infusion bags (Easyflex® and Viaflo® at 25 °C, Freeflex® between 2 and 8 °C, protected from light). |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|