Genetic association of telomere length, obesity and tobacoo smoking with idiopathic pulmonary fibrosis risk

Autor:	Wenjuan Wu, Chenghai Li, Xiaoming Zhu, Xueya Liu, Ping Li, Ruijie Wan, Xinhui Wu, Song Chen
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Idiopathic pulmonary fibrosis Mendelian randomization Obesity Telomere length Tobacco smoking Public aspects of medicine RA1-1270
Zdroj:	BMC Public Health, Vol 23, Iss 1, Pp 1-11 (2023)
Druh dokumentu:	article
ISSN:	1471-2458
DOI:	10.1186/s12889-023-15733-5
Popis:	Abstract Background Due to the inadequacy of published evidence, association of telomere length (TL), obesity and tobacco smoking with idiopathic pulmonary fibrosis (IPF) remains unclear. The aim of the study was to explore whether these exposures genetically affected the risk of the disease. Methods Genetic variants from genome-wide association studies for TL, body mass index (BMI), body fat percentage (BFP) and tobacco smoking (including maternal smoking) were used as instrumental variables. Inverse-variance weighted were mainly adopted to determine the genetic association of these exposures with IPF. All analyses were conducted by R-software (version 3.6.1). Results Firstly, longer TL was associated with the decreased risk of IPF (OR = 0.475 per SD increase in TL, 95%CI = 0.336 ~ 0.670, P
Databáze:	Directory of Open Access Journals
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