Diversity in EWAS: current state, challenges, and solutions

Autor: Charles E. Breeze, Jason Y. Y. Wong, Stephan Beck, Sonja I. Berndt, Nora Franceschini
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Genome Medicine, Vol 14, Iss 1, Pp 1-4 (2022)
Druh dokumentu: article
ISSN: 1756-994X
DOI: 10.1186/s13073-022-01065-3
Popis: Abstract Here, we report a lack of diversity in epigenome-wide association studies (EWAS) and DNA methylation (DNAm) data, discuss current challenges, and propose solutions for EWAS and DNAm research in diverse populations. The strategies we propose include fostering community involvement, new data generation, and cost-effective approaches such as locus-specific analysis and ancestry variable region analysis.
Databáze: Directory of Open Access Journals
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