HIV Infection Indicator Disease-Based Active Case Finding in a University Hospital: Results from the SHOT Project

Autor: Andrea De Vito, Agnese Colpani, Maria Sabrina Mameli, Paola Bagella, Vito Fiore, Claudio Fozza, Maria Antonia Montesu, Alessandro Giuseppe Fois, Fabiana Filigheddu, Noemi Manzoni, Carlo Putzu, Sergio Babudieri, Giordano Madeddu
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Infectious Disease Reports, Vol 15, Iss 1, Pp 94-101 (2023)
Druh dokumentu: article
ISSN: 2036-7449
DOI: 10.3390/idr15010010
Popis: In 2014, UNAIDS launched renewed global targets for HIV control to achieve by 2025, known as “the three 95”: 95% of people living with HIV (PWH) diagnosed, of which 95% are receiving treatment, of which 95% are on sustained virological suppression. In Italy, new HIV diagnoses have been steadily decreasing since 2012. However, in 2020, 41% of new diagnoses presented with less than 200 CD4+ cells/µL and 60% with less than 350 CD4+ cells/µL. Implementing testing and early treatment is a key strategy to prevent AIDS, late presentation, and HIV transmission. We selected non-Infectious Diseases Units based on the European project HIDES and engaged colleagues in a condition-guided HIV screening strategy. We enrolled 300 patients, of which 202 were males (67.3%) and 98 were females (32.7%). Most of the screening was performed in Infectious Diseases (ID) and Hematologic wards. In total, we diagnosed eleven new HIV infections with a hospital prevalence in the study population of 3.7%. Five (45.4%) had a CD4 count 3, one (9.1%) 3, and one (9.1%) 3. Regarding risk factors, 81.8% declared having had unprotected sexual intercourse and 54.5% were heterosexual. All patients promptly started a combination antiretroviral regimen and 10 (90.9%) obtained an undetectable HIV-RNA status. Eight of the eleven (72.7%) patients are currently on follow-up in our outpatient clinic. A proactive indicator disease-guided screening can help avoid missed opportunities to diagnose HIV infection in a hospital setting. Implementing this kind of intervention could favor early diagnosis and access to treatment.
Databáze: Directory of Open Access Journals
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