Genetic evidence for the causal effects of C–reactive protein on self-reported habitual sleep duration

Autor: Olena Iakunchykova, Mengyu Pan, Inge K. Amlien, James M. Roe, Kristine B. Walhovd, Anders M. Fjell, Chi-Hua Chen, Michael E. Benros, Yunpeng Wang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Brain, Behavior, & Immunity - Health, Vol 37, Iss , Pp 100754- (2024)
Druh dokumentu: article
ISSN: 2666-3546
DOI: 10.1016/j.bbih.2024.100754
Popis: Inflammatory responses to acute stimuli are proposed to regulate sleep, but the relationship between chronic inflammation and habitual sleep duration is elusive. Here, we study this relation using genetically predicted level of chronic inflammation, indexed by CRP and IL6 signaling, and self-reported sleep duration. By Mendelian randomization analysis, we show that elevated CRP level within
Databáze: Directory of Open Access Journals