Survival probabilities and prognostic factors of pregnancy-associated breast cancer in Malaysian women
| Autor: | S S Abrar, Bachok Norsa’adah, Maya Mazuwin Yahya, Junaidi A Isa, Erinna M Zon |
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| Jazyk: | English<br />Korean |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Obstetrics & Gynecology Science, Vol 67, Iss 1, Pp 76-85 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2287-8572 2287-8580 |
| DOI: | 10.5468/ogs.23151 |
| Popis: | Objective Pregnancy-associated breast cancer (PABC) is a rare cancer. This study aimed to determine the survival probabilities and prognostic factors in patients with PABC. Methods A retrospective cohort study was conducted in two tertiary care hospitals in Kota Bharu. We included all patients with breast cancer who were diagnosed by histopathology while pregnant or within 2 years post-partum from 2001 through 2020. We matched patients with PABC to non-pregnant patients with breast cancer by age and year of diagnosis. The data were analyzed using Cox proportional hazard regression. Results A total of 35 cases of PABC and 70 non-PABC controls were recruited. The 3-year, 5-year, and 10-year survival probabilities for patients with PABC were 58.6%, 47.54%, and 38.03%, respectively. The patients with PABC had a non-significant difference in survival probabilities compared with non-PABC patients. The significant prognostic factors of PABC were age (adjusted hazard ratio [aHR], 0.91; 95% confidence interval [CI], 0.86–0.96; P=0.001), advanced stage of cancer (aHR, 9.97; 95% CI, 3.96–25.2; P |
| Databáze: | Directory of Open Access Journals |
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